New histopathological evidence for the relationship between hydromyelia and hydrocephalus following subarachnoid hemorrhage: An experimental study

Objectives: Subarachnoid hemorrhage (SAH) is a serious pathology with a high death and morbidity rate. There can be a relationship between hydromyelia and hydrocephalus following SAH; however, this subject has not been well investigated.Materials and Methods: Twenty-four rabbits (3 +/- 0.4 years old; 4.4 +/- 0.5 kg) were used in this study. Five of them were used as the control, and five of them as the SHAM group. The remaining animals (n = 14) had been used as the study group. The central canal volume values at the C1-C2 levels, ependymal cells, numbers of central canal surfaces, and Evans index values of the lateral ventricles were assessed and compared.Results: Choroid plexus edema and increased water vesicles were observed in animals with central canal dilatation. The Evans index of the brain ventricles was 0.33 +/- 0.05, the mean volume of the central canal was 1.431 +/- 0.043 mm(3), and ependymal cells density was 5.420 +/- 879/mm(2) in the control group animals (n = 5); 0.35 +/- 0.17, 1.190 +/- 0.114 mm(3), and 4.135 +/- 612/mm(2) in the SHAM group animals (n = 5); and 0.44 +/- 0.68, 1.814 +/- 0.139 mm(3), and 2.512 +/- 11/mm(2) in the study group (n = 14). The relationship between the Evans index values, the central canal volumes, and degenerated ependymal cell densities was statistically significant (P < 0.05).Conclusions: This study showed that hydromyelia occurs following SAH-induced experimental hydrocephalus. Desquamation of ependymal cells and increased cerebrospinal fluid secretion may be responsible factors in the development of hydromyelia.

Dergi

JOURNAL OF CRANIOVERTEBRAL JUNCTION AND SPINE

Yıl

2023

Cilt

14

Sayı

3

Sayfa

253-258

ISSN

0974-8237

eISSN

0976-9285

DOI

10.4103/jcvjs.jcvjs_67_23

WoS UID

WOS:001082923400007