The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury
Karacaer, C., Erdogan, D. G., Tanyeli, A., Baylan, H., Eraslan, E., Guler, M. C., Polat, E., Comakli, S.
OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was in-vestigated to prove whether it prevents damage to the kidney and lung tissues of rats undergo-ing renal ischemia-reperfusion injury.MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal isch-emia reperfusion), Groups 3 and 4 as pretreat-ment groups (50 HES, 100 HES).RESULTS: According to our results, Hesperi-din pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg.CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reper-fusion injury.
- Dergi
- EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Yıl
- 2023
- Cilt
- 27
- Sayı
- 7
- Sayfa
- 2808-2814
- ISSN
- 1128-3602
- WoS UID
- WOS:000981040900014