Article 2022 · 9 atıf

Comparative heating efficiency and cytotoxicity of magnetic silica nanoparticles for magnetic hyperthermia treatment on human breast cancer cells

Acar, Melek, Solak, Kubra, Yildiz, Seyda, Unver, Yagmur, Mavi, Ahmet

Özet

Magnetic hyperthermia (MHT) is a promising treatment for a variety of cancers due to its ability to increase the sensitivity of cells to other treatments, such as chemotherapy. Superparamagnetic nanoparticles (MNPs) were used for MHT treatment due to their heat generation ability under an AC magnetic field (AMF). In this study, iron oxide and zinc-doped iron oxide MNPs were produced and modified with silica to obtain eleven different types (MSNP-I to -XI) of magnetic silica nanoparticles (MSNPs). The MSNPs which show the highest heating capacity were selected to investigate their MHT ability on non-tumourigenic MCF-10A and tumourigenic MCF-7 cell lines. The cytotoxicity results indicated that the size, the content of the magnetic core and silica coating thickness were important in the heating capacity of MSNPs under AMF. After MHT treatment, selected MSNPs showed limited cytotoxicity on MCF-10A, but significant cell death on MCF-7.

Anahtar Kelimeler

Breast cancer Magnetic nanoparticles Magnetic hyperthermia Iron oxide Zinc-doped iron oxide IRON-OXIDE NANOPARTICLES TARGETED DRUG-DELIVERY NANOCOMPOSITES SIZE APOPTOSIS SPHERES FE3O4

WoS Kategorileri

Biotechnology & Applied Microbiology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: 3 BIOTECH
Yıl: 2022
Cilt: 12
Sayı: 11
ISSN: 2190-572X
eISSN: 2190-5738
DOI: 10.1007/s13205-022-03377-y
WoS UID: WOS:000865190000002

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