Analysis of the nervus vagus effect on gastric adenocarcinoma development

Aim: In this study, we aimed to investigate whether there was an association between a change in the histological composition of the neuroelectrical activity of the vagal nerves and the gastric tumor. Material and Methods: The pathological materials of patients who were operated on in our hospital with the diagnosis of gastric adenocarcinoma were analyzed retrospectively. Tumor cells, vagal nerve and tumor-invading nerve cells were photographed in successive sections at 4x, 10x, 20x and 40x magnifications for stereotypic counts. During the course of the vagal nerve, axon density per square millimeter and neuronal densities were counted. Statistical analysis was performed between the number of degenerated axons, VSI, axon thickness, and tumor stage by scoring according to the tumor size stage (Tumor 1-2-3-4:10). Results: Twelve (44.4%) patients were female and 15 (55.6%) were male, with a mean age of 62.9 +/- 7.7 years. As the tumor grade increased, the difference between the normal axon numbers was found to be significant. Likewise, as the tumor stage increased, there were significant differences between the number of degenerated axons and tumor stage, also there were significant differences between VSI and tumor stage, similarly. Tumor size and axon thickness differences were found to be significant. Discussion: Increased electrical potentials lead to a decrease in apoptosis and an increase in tumorogenesis. In this context, vagal hyperactivity may cause gastric adenocarcinoma. Vagal nerves may become more degenerate in high-grade malignant tumors. Thus, it is concluded that vagal nerve weakness may contribute to the progression of tumors.

Dergi

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE

Yıl

2022

Cilt

13

Sayı

8

Sayfa

923-926

eISSN

2667-663X

DOI

10.4328/ACAM.21167

WoS UID

WOS:000852590900020