Article 2022 · 11 atıf

The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin

Akdemir, Fazile Nur Ekinci, Yildirim, Serkan, Kandemir, Fatih Mehmet

Özet

In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups (n=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-alpha expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration

Anahtar Kelimeler

Apoptosis Cisplatin Evodiamine Liver toxicity Oxidative stress OXIDATIVE STRESS PROCAINAMIDE HYDROCHLORIDE LIVER-DAMAGE RAT-LIVER APOPTOSIS CASPASES TISSUE MECHANISMS THERAPY KIDNEY

WoS Kategorileri

Environmental Sciences

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Yıl: 2022
Cilt: 29
Sayı: 59
Sayfa: 89522-89529
ISSN: 0944-1344
eISSN: 1614-7499
DOI: 10.1007/s11356-022-22007-x
WoS UID: WOS:000827389600005

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