Article 2022 · 16 atıf

Comparison of matrix metalloproteinase 9 and 14 levels in vitreous samples in diabetic and non-diabetic patients: a case control study

Özet

Background MMP-9 plays a prominent role in inflammation and MMP-14 take part in angiogenesis. The objective of this study is to compare MMP-9 and MMP-14 levels between diabetic and non-diabetic patients. Methods The patients who scheduled for pars plana vitrectomy were included in our study. Patients are divided into 2 groups: the diabetic group and non-diabetic group. Age, gender, intraocular pressure(IOP), visual acuity (VA) were reported. Color fundus photography, fundus fluorescein angiography, optic coherence tomography (OCT) were performed before and after the operation. MMP-9 and MMP-14 levels in vitreous samples were analyzed with a reader device by ELISA method. Mann-Whitney U test and logistic regressions were used in statistical analysis, p < 0.05 accepted as statistically significant. Results 70 eyes of 70 patients who received pars plana vitrectomy were enrolled in the study and divided into 2 groups: 34 patients in the diabetic group, 36 patients in the non-diabetic group. The average age of diabetic patients was 60.14 +/- 10.20, and non-diabetic patients was 64.22 +/- 11.16, respectively. The average MMP-9 (0.67 +/- 0.66 ng/ml) and MMP-14 (0.16 +/- 0.45 ng/ml) values in the diabetic group were significantly higher than the average MMP-9 (0.21 +/- 0.05 ng/ml) and MMP-14 (and 0.07 +/- 0.02 ng/ml) values in the non-diabetic group (P < 0.01). Also, it was observed that MMP-9 and MMP-14 levels increases as the diabetic disease duration increases. The risk of diabetes incidence increased with high levels of MMP-9 and MMP-14. Conclusion Due to the higher levels of MMP-9 and MMP-14 in the pathogenesis of diabetic retinopathy, these proteins may probably be among the therapeutic targets in the prevention and treatment of retinopathy.

Anahtar Kelimeler

Matrix metalloproteinase Diabetic retinopathy Pars plana vitrectomy MATRIX METALLOPROTEINASES RETINOPATHY ANGIOGENESIS COMPLICATIONS INHIBITION PREVALENCE INVASION ASPIRIN HEALTH GROWTH

WoS Kategorileri

Ophthalmology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
Yıl: 2022
Cilt: 8
Sayı: 1
eISSN: 2056-9920
DOI: 10.1186/s40942-022-00394-0
WoS UID: WOS:000814236100001

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