Article
2022
·
2 atıf
Transition-Metal-Free Synthesis of 4-Alkynylquinazolines
Özet
Protocols have been developed that allow easy access to 4-alkynylquinazolines under transition-metal-free conditions. The ring opening reaction of 4-(benzofuran-2-yl)quinazolines obtained from the arylation of quinazolines with benzofuran is the first way to achieve 4-alkynylquinazolines. Direct alkynylation of quinazolines with terminal alkynes in the presence of n-BuLi and iodine or with alkynyl Grignard reagents is another strategy. Desilylation of 4-((trimethylsilyl)ethynyl)quinazolines obtained by direct alkynation is the third approach to give 4-alkynylquinazolines. It has also been shown that the protocols are applicable for scale-up synthesis.
Anahtar Kelimeler
Alkynylation
Aromatic substitution
C-C coupling
Ring opening
Synthetic methods
QUINAZOLINE
SERIES
CONSTRUCTION
CYCLIZATION
CONVENIENT
WoS Kategorileri
Chemistry, Organic
Sürdürülebilir Kalkınma Amaçları
Künye
- Dergi
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Yıl
- 2022
- Cilt
- 2022
- Sayı
- 13
- ISSN
- 1434-193X
- eISSN
- 1099-0690
- DOI
- 10.1002/ejoc.202200131
- WoS UID
- WOS:000776644000001