Article 2021 · 5 atıf

Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties

Cagatay, Elcin, Akyildiz, Volkan, Ergun, Yavuz, Kayali, Hulya Ayar

Özet

A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.

Anahtar Kelimeler

murrayaquinone A organic synthesis anti-tumor activity colon cancer cell lines CELL-CYCLE ARREST HYDROGEN-PEROXIDE OXIDATIVE STRESS SERUM-ALBUMIN APOPTOSIS CANCER BINDING DEATH CARBAZOLEQUINONES CYTOTOXICITY

WoS Kategorileri

Biochemistry & Molecular Biology Chemistry, Multidisciplinary

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: CHEMISTRY & BIODIVERSITY
Yıl: 2021
Cilt: 18
Sayı: 11
ISSN: 1612-1872
eISSN: 1612-1880
DOI: 10.1002/cbdv.202100348
WoS UID: WOS:000698189900001

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