Article 2021 · 13 atıf

Antibacterial properties and carbonic anhydrase inhibition profiles of azido sulfonyl carbamate derivatives

Guller, Pinar, Atmaca, Ufuk, Guller, Ugur, Calisir, Ulas, Dursun, Feray

Özet

Aim: The aim of this study was to identify inhibition of carbonic anhydrase I and II (CA I and II) isozymes by azido sulfonyl carbamates through both in vitro and in silico approaches and also to determine the drug-likeness properties and antibacterial activities of azido sulfonyl carbamates. Methods & Results: In vitro inhibition and molecular docking studies of azido sulfonyl carbamate derivatives (1-4) on isozymes were performed. Except for derivative 4, all derivatives inhibited human CA I and II. Almost all compounds had antibacterial effects. The docking results showed that compound 3 had the best results, with binding energy of -8.20 kcal/mol for human CA I and -8.24 kcal/mol for human CA II. Conclusion: Molecule 4 inhibited only CA I. Its usage as a potential chemotherapeutic agent specific to the CA I isozyme may be considered.

Anahtar Kelimeler

antibacterial azido sulfonyl carbamate carbonic anhydrase drug likeness structure-activity relationship THERAPEUTIC APPLICATIONS ANTIMICROBIAL ACTIVITY DRUGS ANTICANCER DISCOVERY IX

WoS Kategorileri

Chemistry, Medicinal

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: FUTURE MEDICINAL CHEMISTRY
Yıl: 2021
Cilt: 13
Sayı: 15
Sayfa: 1285-1299
ISSN: 1756-8919
eISSN: 1756-8927
DOI: 10.4155/fmc-2020-0387
WoS UID: WOS:000658301100001

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