Article 2021 · 12 atıf

The impact of COVID-19 on familial Mediterranean fever: a nationwide study

Gunendi, Zafer, Yurdakul, Fatma Gul, Bodur, Hatice, Cengiz, Ahmet Kivanc, Ucar, Ulku, Cay, Hasan Fatih, Sen, Nesrin, Keskin, Yasar, Gurer, Gulcan, Melikoglu, Meltem Alkan, Altintas, Duygu, Deveci, Hulya, Baykul, Merve, Nas, Kemal, Cevik, Remzi, Karahan, Ali Yavuz, Toprak, Murat, Ketenci, Sertac, Nayimoglu, Mehmet, Sezer, Ilhan, Demir, Ali Nail, Ecesoy, Hilal, Duruoz, Mehmet Tuncay, Yurdakul, Ozan Volkan, Sarifakioglu, Ayse Banu, Ataman, Sebnem

Özet

The study aimed to evaluate the impact of the coronavirus disease 2019 (COVID-19) in patients with familial Mediterranean fever (FMF) and to assess the relationships between FMF characteristics and severe COVID-19 outcomes such as hospitalization. The study was planned within a national network of 21 different centers. Demographics, FMF-related clinical and genetic characteristics, and COVID-19 outcomes were obtained. A total of 822 patients with FMF (mean age of 36 years) were included in the study. Fifty-nine of them (7%) had a COVID-19 diagnosis confirmed by real-time PCR test or chest CT findings. Most FMF patients with COVID-19 (58) had mild and moderate disease activity. All patients were on colchicine treatment. However, 8 of them (13.6%) were not compliant with colchicine use and 9 of them (15.3%) were colchicine resistant. Twelve FMF patients with COVID-19 were hospitalized. There were 4 patients requiring oxygen support. COVID-19 related complications were observed in 2 patients (1 thromboembolism, 1 acute respiratory distress syndrome). Hospitalized COVID-19 patients with FMF were older than non-hospitalized patients (median ages: 51 and 31 years, respectively; p: 0.002). Other FMF-related characteristics were similar between the groups. FMF-related characteristics were not found to be associated with poor outcomes in COVID-19. Thus, FMF may not be a risk factor for poor COVID-19 outcomes.

Anahtar Kelimeler

COVID-19 Familial Mediterranean fever Rheumatic diseases Colchicine Hospitalization Poor outcomes

WoS Kategorileri

Rheumatology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: RHEUMATOLOGY INTERNATIONAL
Yıl: 2021
Cilt: 41
Sayı: 8
Sayfa: 1447-1455
ISSN: 0172-8172
eISSN: 1437-160X
DOI: 10.1007/s00296-021-04892-6
WoS UID: WOS:000654089100002

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