Article 2021 · 26 atıf

Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout <i>Oncorhynchus mykiss</i>, Walbaum

Ucar, Arzu, Parlak, Veysel, Cilingir Yeltekin, Asli, Ozgeris, Fatma Betul, Caglar, Ozge, Turkez, Hasan, Alak, Gonca, Atamanalp, Muhammed

Özet

In this study, changes in the blood tissue of rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) caused by Fipronil (FP) insecticide were investigated using different biomarkers (Hematology parameters, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), malondialdehyde (MDA), paraoxonase (PON), arylesterase (ARE), myeleperoxidase (MPO), micronucleus (MN), 8-hydroxy-2-deoxyguanosine (8-OHdG)) level and caspase-3 activity. Statistically significant alterations in hematology parameters occurred with FP effect. In blood tissue, dose-dependent inhibition was determined in SOD-CAT-GPX-PON and ARE enzyme activities, but MDA and MPO were induced statistically significant. The results of MN assay were compared with the control group and it was obtained that genotoxicity of different dose groups was similar. The level of 8-OHdG and the activity and caspase-3 examined in blood tissue was increased depending on the dose. It was determined with different biomarkers that this insecticide caused physiological stress changes in the tissues examined.

Anahtar Kelimeler

Fipronil O mykiss hematology enzyme parameters 8-OHdG caspase-3 MICRONUCLEUS TEST COPPER-SULFATE DNA-DAMAGE ANTIOXIDANT LIVER EXPOSURE DELTAMETHRIN ERYTHROCYTES COMBINATION PARAMETERS

WoS Kategorileri

Toxicology

Künye

Dergi: TOXICOLOGY MECHANISMS AND METHODS
Yıl: 2021
Cilt: 31
Sayı: 1
Sayfa: 73-80
ISSN: 1537-6516
eISSN: 1537-6524
DOI: 10.1080/15376516.2020.1831122
WoS UID: WOS:000583825800001

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