Article 2021 · 4 atıf

Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

Korkmaz, Ufuk Turan Kursat, Yuksel, Ahmet, Cetinkaya, Ayhan, Velioglu, Yusuf, Ucaroglu, Erhan Renan, Cayir, Mustafa Cagdas, Kumtepe, Gencehan, Borulu, Ferhat, Bal, Ceylan, Erdem, Kemalettin, Gok, Gamze, Devay, Seda Duygulu

Özet

Objective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case-control study. Participants' baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group (p = 0.045,p = 0.000 andp = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group (p = 0.000,p = 0.000 andp = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.

Anahtar Kelimeler

Thiol disulphide homeostasis oxidative stress novel risk factor biomarker peripheral arterial disease VASCULAR OXIDATIVE STRESS NITRIC-OXIDE PARAMETERS ALBUMIN PLASMA

WoS Kategorileri

Peripheral Vascular Disease

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: VASCULAR
Yıl: 2021
Cilt: 29
Sayı: 2
Sayfa: 248-255
ISSN: 1708-5381
eISSN: 1708-539X
DOI: 10.1177/1708538120947245
WoS UID: WOS:000559615800001

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