Article 2021 · 21 atıf

An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities

Algul, Oztekin, Ersan, Ronak Haj, Alagoz, Mehmet Abdullah, Duran, Nizami, Burmaoglu, Serdar

Özet

A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated forin vitrocytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that23, 26and29exhibit better activity against HepG2 and HeLa cancer cell lines. Compound23also showed good activity against A549, and A498 cancer cell lines. The analogs were further performed molecular docking studies against human cytochrome P450 2C8 monooxygenase enzyme, calculated some theoretical quantum parameters, ADMET descriptor and molecular electrostatic potential analysis. The strategy applied in this research work may act as a perspective for the rational design of potential anticancer drugs. Communicated by Ramaswamy H. Sarma

Anahtar Kelimeler

Di-heterocyclic structure benzimidazole benzothiazole benzoxazole benzazole polyphosphoric acid antiproliferative activity molecular docking ADMET BENZIMIDAZOLES COMPLEXES POTENT BENZOTHIAZOLYL METABOLITE BINDING

WoS Kategorileri

Biochemistry & Molecular Biology Biophysics

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Yıl: 2021
Cilt: 39
Sayı: 18
Sayfa: 6926-6938
ISSN: 0739-1102
eISSN: 1538-0254
DOI: 10.1080/07391102.2020.1803966
WoS UID: WOS:000557611000001

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