BIOORGANIC CHEMISTRY

Targeting cholinergic dysfunction and neuroinflammation through rationally designed Thieno[3,2-d]pyrimidine hybrids

Design, synthesis,<i> in</i><i> vitro</i> and<i> in</i><i> silico</i> evaluation of thiazole-hydrazine hybrids incorporating an isoindole-1,3-dione scaffold as potent α-glucosidase inhibitors

Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality

Synthesis and evaluation of sulfonamide-chalcone hybrid compounds as inhibitors of VEGFR1/VEGFR2-mediated angiogenesis

Synthesis of novel benzene bissulfonamides with carbonic anhydrase and choline esterase inhibitory properties

Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies

Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies

Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma

Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma

Design, synthesis and anticholinergic properties of novel <i>α</i>-benzyl dopamine, tyramine, and phenethylamine derivatives

Design, synthesis, characterization, crystal structure, in silico studies, and inhibitory properties of the PEPPSI type Pd(II)NHC complexes bearing chloro/fluorobenzyl group

Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit docking studies

Selenourea and thiourea derivatives of chiral and achiral enetetramines: Synthesis, characterization and enzyme inhibitory properties

Investigation of carbonic anhydrase inhibitory effects and cytotoxicities of pyrazole-based hybrids carrying hydrazone and zinc-binding benzenesulfonamide pharmacophores

Synthesis and aldose reductase inhibition effects of celecoxib derivatives containing pyrazole linked-sulfonamide moiety

Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase enzymes

Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from Lawsone

Synthesis, design, and assessment of novel morpholine-derived Mannich bases as multifunctional agents for the potential enzyme inhibitory properties including docking study

Synthesis of novel 1,2,3 triazole derivatives and assessment of their potential cholinesterases, glutathione S-transferase enzymes inhibitory properties: An <i>in vitro</i> and <i>in silico</i> study

Exploring of tumor-associated carbonic anhydrase isoenzyme IX and XII inhibitory effects and cytotoxicities of the novel <i>N</i>-aryl-1-(4-sulfamoylphenyl)-5-(thiophen-2-yl)-1<i>H</i>-pyrazole-3-carboxamides

Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents