Demir, Yeliz

Evaluation of 2-Aminothiazoles as α-Glucosidase Inhibitors: DFT, Molecular Docking, and Antioxidant Studies

New silver N-heterocyclic carbene (NHC) complexes containing fluoro and acetyl groups: design, characterization, molecular docking studies, and inhibition properties against several metabolic enzymes

Integrated bioinformatics and molecular docking ıdentify <i>CCNB1</i>, <i>CDK1</i>, and <i>CYP1A2</i> as therapeutic targets of phytochemicals in hepatocellular carcinoma

1,4-Naphthoquinone thiazole urea hybrids bearing morpholine/piperazine: synthesis, crystal structure, aldose reductase and α-glycosidase enzyme inhibition, molecular docking, and electrochemical interaction with dsDNA

Esculetin attenuates doxorubicin-induced cardiac toxicity: Evidence from gene expression, enzyme activity, and molecular docking analyses

Morpholine-modified thiosemicarbazones and thiazolidin-4-ones against Alzheimer's key enzymes: From synthesis to inhibition

Bioinformatics-Based Discovery of Therapeutic Targets in Cadmium-Induced Lung Adenocarcinoma: The Role of Oxyresveratrol

Mechanistic Insights into the Biological Effects of <i>Aronia melanocarpa</i> Through <i>In vitro</i> Assays, Molecular Docking and Bioinformatic Analysis

Targeting cholinergic dysfunction and neuroinflammation through rationally designed Thieno[3,2-d]pyrimidine hybrids

Integrative Bioinformatic Identification and Molecular Docking of Quercetin and Sulforaphane-Associated Prognostic Targets in Pancreatic Adenocarcinoma

Systems-level integration of machine learning, SHAP explainability, PCA, and network topology reveals multitarget protective actions of tannic acid against doxorubicin toxicity in pentose phosphate pathway

Unnatural amino acid compounds as potent multi-target inhibitors of aldose reductase, α-glucosidase, and α-amylase: integrated in vitro, SAR, and molecular dynamics insights

Design, synthesis,<i> in</i><i> vitro</i> and<i> in</i><i> silico</i> evaluation of thiazole-hydrazine hybrids incorporating an isoindole-1,3-dione scaffold as potent α-glucosidase inhibitors

Synthesis of novel bromophenolic sulfonamides with their acetylcholinesterase and carbonic anhydrase inhibitory actions

Bioactive Potential of <i>Hippophae rhamnoides</i> L. Extracts: Comparative Antioxidant, Antimicrobial, and Enzyme Inhibitory Effects

Biochemical markers of muscle damage and recovery: Insights from exercise physiology and molecular biology

Integrative analysis of <i>Cichorium intybus</i> L. Extracts: from NADES-Based extraction and UHPLC-Orbitrap®-HRMS to bioinformatics and machine learning

Synthesis, characterization, and lipoxygenase inhibition of salicylaldehyde-derived schiff base metal complexes: enzymatic and in silico evaluation using quinoa lipoxygenase

Antioxidant and antimicrobial activities of different extracts of Tragopogon dubius and Tragopogon porrifolium L. subsp. longirostris: Determination of their phytochemical contents by UHPLC-Orbitrap®-HRMS analysis

Benzimidazolium salts bearing ester group: Synthesis, characterization, crystal structure, molecular docking studies, and inhibitory properties against metabolic enzymes

Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as multitarget acetylcholinesterase and carbonic anhydrase inhibitors

Structure-based inhibition of acetylcholinesterase and butyrylcholinesterase with 2-Aryl-6-carboxamide benzoxazole derivatives: synthesis, enzymatic assay, and <i>in silico</i> studies

New Mannich-type arylidenerhodanines as potent inhibitors of AChE and BChE: synthesis, biological evaluation, cytotoxicity and molecular modeling

Rhodanine-Sulfonate hybrids targeting aldose reductase: Synthesis, in vitro inhibition, molecular docking, and cytotoxicity studies

Esculetin Attenuates Doxorubicin-Induced Cardiotoxicity via Modulation of Apoptotic and Mitochondrial Gene Expression Networks

Design, Synthesis, and In Silico Analyses of Nitroimidazole Derivatives Targeting Cholinesterases

Phenolic Compounds in Exercise Physiology: Dual Role in Oxidative Stress and Recovery Adaptation

Synthesis, Biological Evaluation and Molecular Docking of Novel Sulfonamide Derivatives as Dual Inhibitors of Carbonic Anhydrase Isoenzymes I/II and Acetylcholinesterase

Antidiabetic properties of dihydrooxazole Derivatives:<i> In</i><i> vitro</i> and<i> in</i><i> silico</i> evaluation as potential aldose reductase and α-glucosidase inhibitors

Imidazol-2-Ylidene-Silver(I) Complexes Bearing 4-Acetylphenyl Side Arm: Design, Synthesis, Characterization, Crystal Structure, and Inhibitory Properties Against Some Metabolic Enzymes

Protective Effects of Hispidulin Against Oleic Acid-induced Acute Kidney Injury in Rats: Integrated Enzymatic and Molecular Docking Analysis

New 1,2,3-triazole derivatives as acetylcholinesterase and carbonic anhydrase inhibitors: Synthesis, molecular docking, and solubility

Quinazolin-4(3<i>H</i>)-One-Based New Glitazones as Dual Inhibitors of α-Glucosidase and Aldose Reductase: Comprehensive Approaches for Managing Diabetes Mellitus and Its Complications

Synthesis of novel pyrazino[1,2-a]indol-1(2H)-one derivatives as potent cholinesterase inhibitors and their in vitro and in silico evaluations

A new series of naphthyl-thiosemicarbazone and thio/carbohydrazone derivatives: Synthesis, spectroscopic elucidation, dual enzyme inhibition targeting carbonic anhydrase/acetylcholinesterase and molecular docking studies

Development of phenolic Mannich bases as α-glucosidase and aldose reductase inhibitors:<i> In</i><i> vitro</i> and<i> in</i><i> silico</i> approaches for managing diabetes mellitus and its complications

Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality

Discovery of Dual-Inhibitor Acyl Hydrazones for Acetylcholinesterase and Carbonic Anhydrase I/II: A Mechanistic Insight into Alzheimer's Disease

Some Novel Oxirane-Thiirane Derivatives: Synthesis, Molecular docking and Enzymatic Inhibition for Therapeutic Potential

Design, synthesis, and inhibition of α-glucosidase by novel L-phenylalanine-derived hydrazones: Kinetic, molecular docking, and dynamics studies

Determination of the Inhibitory Potential of Chalcones on Myeloperoxidase Enzyme Activity: In vitro and Molecular Docking Studies

New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: Synthesis, crystal structure, molecular docking, and acid dissociation constant

Protective effect of bromelain on some metabolic enzyme activities in tyloxapol-induced hyperlipidemic rats

Esculetin improves inflammation of the kidney via gene expression against doxorubicin-induced nephrotoxicity in rats:<i> In</i><i> vivo</i> and<i> in</i><i> silico</i> studies

The protective effects of esculetin against Doxorubicin-Induced hepatotoxicity in rats: Insights into the modulation of Caspase, FOXOs, and heat shock protein pathways

The hepatoprotective potential of tannic acid against doxorubicin-induced hepatotoxicity: Insights into its antioxidative, anti-inflammatory, and antiapoptotic mechanisms

Bioactivity, cytotoxicity, and molecular modeling studies of novel sulfonamides as dual inhibitors of carbonic anhydrases and acetylcholinesterase

Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic enzymes

Investigation of Some Metabolic Enzyme Inhibition Properties of Novel Chalcone-Cu Complexes

Effects of Carnosic and Usnic Acid on Pentose Phosphate Pathway Enzymes: An Experimental and Molecular Docking Study

Effect of tannic acid on doxorubicin-induced cellular stress: Expression levels of heat shock genes in rat spleen

Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes

Synthesis of 1,3-Disubtitituted Tetrahydropyrimidinium Salts and Determination of Their Biological Properties and Molecular Docking

Bisbenzimidazole salts and their in silico-in vitro inhibitory abilities on hCA I, hCA II, and AChE enzymes

Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase

Protective effects of esculetin against doxorubicin-induced toxicity correlated with oxidative stress in rat liver: In vivo and in silico studies

Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies

Novel benzene sulfonamides with acetylcholinesterase and carbonic anhydrase inhibitory actions

Naringenin, Hesperidin and Quercetin Ameliorate Radiation-Induced Damage In Rats: In Vivo And In Silico Evaluations

Organohalogen chalcones: design, synthesis, ADMET prediction, molecular dynamics study and inhibition effect on acetylcholinesterase and carbonic anhydrase

Production, purification and characterization of novel fibrinolytic enzyme from <i>Bacillus atrophaeus</i> V4

Assessment of hypolipidemic and anti-inflammatory properties of walnut (<i>Juglans regia</i>) seed coat extract and modulates some metabolic enzymes activity in triton WR-1339-induced hyperlipidemia in rat kidney, liver, and heart

Acetylphenyl-substituted imidazolium salts: synthesis, characterization, in silico studies and inhibitory properties against some metabolic enzymes

Molecular Docking Studies and the Effect of Fluorophenylthiourea Derivatives on Glutathione-Dependent Enzymes

Synthesis and characterization of novel acyl hydrazones derived from vanillin as potential aldose reductase inhibitors

Benzimidazolium Salts Bearing Nitrile Moieties: Synthesis, Enzyme Inhibition Profiling, and Molecular Docking Analysis for Carbonic Anhydrase and Acetylcholinesterase

Screening of <i>in Vitro</i> Inhibition of Lactoperoxidase Enzyme by Methyl Benzoate Derivatives with Molecular Docking Studies

Ornamental cabbage (<i>Brassica oleracea</i> var. acephala) responses to phytase enzyme purified from <i>Lactobacillus coryniformis</i> application

Fluorinated benzimidazolium salts: Synthesis, characterization, molecular docking studies and inhibitory properties against some metabolic enzymes

Exploration of Some Bis-Sulfide and Bis-Sulfone Derivatives as Non-Classical Aldose Reductase Inhibitors

Synthesis and inhibition profiles of N-benzyl- and N-allyl aniline derivatives against carbonic anhydrase and acetylcholinesterase - A molecular docking study

Some indazoles as alternative inhibitors for potato polyphenol oxidase

Discovery of sulfadrug-pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors

Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3<i>H</i>)-one derivatives as potential aldose reductase inhibitors

Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes

The effect of brimonidine and proparacaine on metabolic enzymes: Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase

Benzimidazolium Salts Containing Trifluoromethoxybenzyl: Synthesis, Characterization, Crystal Structure, Molecular Docking Studies and Enzymes Inhibitory Properties

Phthalimide-tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies

The palladium-based complexes bearing 1,3-dibenzylbenzimidazolium with morpholine, triphenylphosphine, and pyridine derivate ligands: synthesis, characterization, structure and enzyme inhibitions

Investigation of The Effect of Acylthiourea Derivatives on Diabetes-Associated Enzymes

Synthesis of Novel Bromophenol with Diaryl Methanes-Determination of Their Inhibition Effects on Carbonic Anhydrase and Acetylcholinesterase

Screening of in vitro and in silico effect of Fluorophenylthiourea compounds on glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase enzymes

Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors

Isolation of Some Phenolic Compounds from <i>Plantago subulata</i> L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity

SYNTHESIS AND ENZYME INHIBITORY PROPERTIES OF QUINOXALINE BRIDGED BIS(IMIDAZOLIUM) SALTS

Design, synthesis, biological evaluation and molecular docking studies of novel 1<i>H</i>-1,2,3-Triazole derivatives as potent inhibitors of carbonic anhydrase, acetylcholinesterase and aldose reductase

Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies

Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline-benzenesulfonamide derivatives harboring phenol/polyphenol moieties

Cytotoxic effect, enzyme inhibition, and in silico studies of some novel <i>N</i>-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif

New Pd(II) complexes of the bisthiocarbohydrazones derived from isatin and disubstituted salicylaldehydes: Synthesis, characterization, crystal structures and inhibitory properties against some metabolic enzymes

Calcium Channel Blockers: The Effect of Glutathione S-Transferase Enzyme Activity and Molecular Docking Studies

Novel Mannich bases with strong carbonic anhydrases and acetylcholinesterase inhibition effects: 3-(aminomethyl)-6-{3-[4-(trifluoromethyl)phenyl]acryloyl}-2(3<i>H</i>)-benzoxazolones

Synthesis, characterization, crystal structure and bioactivities of novel enamine and pyrrole derivatives endowed with acetylcholinesterase, α-glycosidase and human carbonic anhydrase inhibition effects

Synthesis of <i>N</i>-alkylated pyrazolo[3,4-<i>d</i>]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone-based benzenesulfonamides

Synthesis of benzamide derivatives with thiourea-substituted benzenesulfonamides as carbonic anhydrase inhibitors

Synthesis and in silico studies of triazene-substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors

Purification of the phytase enzyme from<i>Lactobacillus plantarum</i>: The effect on pansy growth and macro-micro element content